Reduced common cold duration

• In 2013 The Cochrane Database of Systematic Reviews published a meta-analysis of 29 trials involving 11,306 participants which found that, while regular vitamin C supplementation could reduce the duration and severity of colds, it was not effective in preventing of the common cold. [Source]
• In 2006 Annals of Nutrition & Metabolism published a review of various clinical trials for which the authors concluded that adequate intake of vitamin C and zinc can reduce the severity and duration of cold symptoms while also reducing the incidence of pneumonia, malaria and diarrhea, particularly in children in developing countries. [Source]

Wrist fracture

• In 2007 The Journal of Bone and Joint Surgery published a double-blind study in which 416 patients with wrist fractures received either a placebo or 200, 500, or 1500 mg of vitamin C daily for 15 days. The groups who received vitamin C had significantly fewer patients experience complex regional pain syndrome (CPRS). [Source]

Reduced inflammation

• In 2015 Drug Design, Development and Therapy published a study in which 64 obese patients with diabetes and/or hypertension and high levels of inflammation were assigned to a control group or given 500 mg vitamin C twice daily. After 8 weeks key inflammatory markers were significantly reduced in the treatment group, compared to no changes in the control group. [Source]
• In 2013 the International Journal of Pediatric Endocrinology published a double-blind study in which 40 obese adolescent boys were given 500 mg vitamin C or a placebo twice daily for 8 weeks. A measurement determining inflammation and cardiovascular risk (known as ICAM-1) taken before and after treatment for both groups showed that vitamin C supplementation significantly reduced ICAM-1 concentrations. [Source]

Vitamin C deficiency – Increased inflammation and impaired vascular function

• In 2011 the Journal of the American Dietetic Association published a study involving 8 obese and 8 lean college aged males which found that low vitamin C status was associated with systemic inflammation and impaired vascular function in both lean and obese men. [Source]

Prevalent in obese individuals

• In 2008 The American Journal of Clinical Nutrition published a study in which vitamin status was measured in 110 morbidly obese patients and 58 healthy controls. Results showed that the morbidly obese patients had significantly lower levels of vitamins C, B6, D and E. [Source]
• In 2013 Nutrients published a study including 197 children which found that low vitamin C and vitamin E concentrations were associated with obesity. Additionally, vitamin C, A and E concentrations were negatively correlated with inflammatory markers. [Source]

Topical vitamin C – Reduced wrinkles and increased collagen production

• In 2002 Dermatology Surgery published a double-blind study in which 10 subjects applied a 10 percent vitamin C complex to half the face and a gel-base (placebo) to the other half of the face for 12 weeks. Clinical evaluation showed visible improvements in wrinkles and photo damaged skin on the vitamin-C-treated side of the face and skin biopsies confirmed new collagen formation. [Source]

Topical vitamin C – Increased collagen production

• In 2015 Clinical, Cosmetic and Investigational Dermatology published a study involving 60 female subjects which found that topically applied vitamin C was highly efficient in rejuvenating facial skin and triggering a significant increase in collagen production with minimal side effects. [Source]

Topical vitamin C – Improves photodamaged skin

• In 2003 Experimental Dermatology published a 6-month, double-blind study which found that a 5 percent vitamin C cream applied to the lower neck and arms of women with photo-damaged skin lead to improvements in the structure of skin as well as visible improvements in skin appearance and deep wrinkles when compared to a placebo cream. [Source]
• In 2012 the Journal of Drugs in Dermatology published a study in which 20 women with photo-aged skin treated one side of the face with 23.8 percent vitamin C serum once daily for 2 weeks. Seventy-five percent of participants rated overall satisfaction as good or excellent with significant improvements in dyspgmentation, roughness, and fine lines. [Source]

Topical vitamin C – prevention against skin aging

• In 2004 BMC Dermatology published a study which found that 4 months of daily treatment with a 3 percent vitamin C cream on the inner forearm of 33 women enhanced the density of dermal papillae compared to a controlled cream – which may help prevent skin aging. [Source]

Inversely associated with Prostate cancer

• In 2015 the Journal of Cancer published a meta-analysis of 18 studies involving 103,658 subjects which found an inverse relationship between dietary vitamin C and prostate cancer risk. [Source]

Reduced risk for heart disease

• In 2003 the Journal of the American College of Cardiology published a study based on dietary and supplementation surveys completed by 85,118 female nurses. After 16 years of follow-up it was determined that vitamin C supplementation was associated with reduced risk for coronary heart disease. [Source]

Restless leg syndrome

• In 2012 Sleep Medicine published a double-blind study including 60 patients which found that, compared to a placebo, both vitamins C (200 mg) and E (400 mg) combined and taken separately significantly reduced restless leg syndrome scores. [Source]

Cancer Patients – Improved quality of life

• In 2007 the Journal of Korean Medical Science published a study in which 39 terminal cancer patients were given 2 intravenous doses of 10 grams of vitamin C with 3 days between doses, along with an oral intake of 4 grams vitamin C daily for a week. After administration, patients reported significantly higher scores for physical, emotional and cognitive function and significantly lower scores for fatigue, nausea, vomiting, pain and appetite loss. [Source]

Advanced cancer

• In 2015 the Public Library of Science published a study in which 3 of 14 advanced cancer patients treated with intravenous vitamin C saw increased energy and functional improvement. The authors note that intravenous vitamin C is often ignored as a treatment option by academic cancer investigators, but that it possesses potential and should be studied in more focused clinical trials. [Source]

Reduced inflammation in cancer patients

• In 2012 the Journal of Transitional Medicine Published a study in which 45 cancer patients were treated with high dose intravenous vitamin C (7.5-50 g) after conventional treatments. The results showed that 75 percent of patients saw a significant reduction in various inflammatory markers, including C-reactive protein. Additionally, reductions in inflammation correlated with decreases in tumor marker levels. [Source]

Neurofibromatosis

• In 2016 The American Journal of Case Reports published a case report of a 5-year-old child with neurofibromatosis (A condition that causes tumors to form in the brain, spinal cord, and nerves) who after chemotherapy saw continued progression of the disease. The child was then treated, for 30 months, with IVC (intravenous vitamin C) and saw reduction of tumors and complete remission of one tumor. [Source]

Pancreatic Cancer

• In 2015 Scientific Reports published a meta-analysis of 17 studies including 4,827 cancer patients which showed that the highest vitamin C intake was associated with the lowest risk for pancreatic cancer. [Source]

Anti-fatigue

• In 2012 Nutrition Journal published a double-blind clinical trial in which 141 healthy office workers received either 10 grams of IVC (intravenous vitamin C) or a placebo (in IV form). Fatigue scores measured both 2 hours and one day after administration were significantly lower in participants of the vitamin C group who had low baseline levels of vitamin C. [Source]

Anxiety reduction

• In 2015 the Pakistan Journal of Biological Sciences published a double-blind trial in which 42 high school students received either 500 mg vitamin C or a placebo daily for 14 days. After treatment the vitamin C group recorded lower anxiety scores and higher vitamin C levels. [Source]
• In 2013 the Pakistan Journal of Biological Sciences published a study in which 45 diabetic patients were treated with either vitamin C, vitamin E or a placebo for 6 weeks. After supplementation only the vitamin-C-treated group showed significant decreases in anxiety. [Source]

Depression

• In 2013 Nutrition Journal published a 6-month, double-blind, placebo-controlled trial in which 12 patients given fluoxetine (prozac) with 1000 mg vitamin C daily showed greater improvements on two depression rating scales when compared to 12 patients given fluoxetine with a placebo. [Source]

Dialysis

• In 2013 Nephro-urology Monthly published a double-blind trial in which 151 dialysis patients were either assigned to a control group (no treatment) or received either 250 mg of intravenous vitamin C or a placebo (saline) 3 times weekly for 8 weeks. At the end of the treatment period the vitamin C group had a significant reduction in C-reactive protein (a key inflammatory marker) compared to either control group. [Source]

Type 2 Diabetes

• In 2011 Advances in Pharmacological Sciences published a double-blind, placebo-controlled trial involving 70 type 2 diabetic patients in which significant improvements in glycemic control and diabetic related markers were seen when combining metformin (diabetes drug) with oral vitamin C supplementation for 12 weeks. [Source]

Reduced oxidative stress in athletes

• In 2013 the International Journal of Preventative Medicine published a 64-subject, double-blind, 4-week trial which found that vitamins C and E reduced muscle damage markers of aerobic exercise. [Source]

Reduced cholesterol

• In 2006 the Journal of Chiropractic Medicine published a meta-analysis of 51 studies published between 1966 and 2004 which found that individuals with high and severe cholesterol levels possessed lower vitamin C levels compared to individuals with normal cholesterol. The authors note that supplementation may help improve vitamin C levels in those with lower-than-normal vitamin C and thus help lower cholesterol. [Source]