Alzheimer’s

• In 2014 the Journal of Alzheimer’s Disease published an animal study which showed that long-term resveratrol supplementation significantly prevented memory loss in an Alzheimer’s mouse model, while also reducing beta-amyloid concentrations. [Source]
• In 2013 Age published an animal study which found that resveratrol supplementation was able to increase life expectancy in an Alzheimer’s mouse model, while also reducing cognitive impairment and decreasing amyloid levels. [Source]
• In 2013 Neural Regeneration Research published an animal study which found that daily resveratrol administration in rats with dementia improved maze test escape times. Researchers also found increased levels of the antioxidant, glutathione and the protective enzyme, superoxide dismutase in regions of the brain. [Source]
• In 2015 Current Alzheimer’s Research published an in vitro study which found that resveratrol was able to protect neuron cells through various mechanisms, while improving the expression of memory-associated proteins. [Source]
• In 2016 Oncotarget published an animal study in which resveratrol was able to reverse memory and learning impairment in mice by preventing neuroinflammation and increasing brain-derived neurotrophic factor – an important protein for brain function. [Source]
• In 2009 Rejuvenation Research published an animal study which showed that resveratrol may be effective in treating cognitive disorders in elderly individuals with an infection. [Source]

Anti-aging – Prevents age related brain decline

• In 2015 Age published an animal study which found that resveratrol treatment prevented decline of serotonin, dopamine and noradrenaline levels in rats which helped restore working memory. [Source]
• In 2016 Neurobiology of Learning and Memory published an animal study which found that resveratrol reversed age-related learning deficits and memory impairment in rats, through its anti-inflammatory properties. [Source]
• In 2015 Age published an animal study which showed that 4 weeks of resveratrol administration reversed age related decline in rats by preventing the decline of neurotransmitters serotonin, dopamine and noradrenaline. [Source]

Colitis

• In 2015 Archives of Medical Research published a 50-patient, double-blind, placebo-controlled study which found that 6 weeks of 500 mg/day resveratrol supplementation lead to a significant reduction in tumor necrosis factor – a protein involved in systemic inflammation. Patients also saw significant improvement in colitis index scores. [Source]
• In 2016 Archives of Medical Research published a double-blind, placebo-controlled study in which 56 colitis patients were assigned to either 500 mg/day resveratrol or a placebo for 6 weeks. Resveratrol improved both disease activity and quality of life in patients with ulcerative colitis. [Source]
• In 2004 Biochemical Pharmacology published an animal study which found that resveratrol reduced the damage caused by experimentally induced colitis in rats. [Source]
• In 2011 Cancer Prevention Research published an animal study which found that resveratrol reduced colon tumor incidence by 80 percent (when tumors were induced) and protected mice from induced colitis. [Source]
• In 2010 Archives of Medical Research published an animal study which showed that resveratrol had “marked inhibitory effects” on ulcerative colitis in mice. [Source]
• In 2006 the British Journal of Pharmacology published an animal study which showed that resveratrol reduced damage in experimentally induced colitis in rats. [Source]
• In 2009 the Journal of Agricultural and Food Chemistry published an animal study which found that resveratrol increased beneficial gut bacteria in rats and reduced harmful bacteria upon treatment with dextran sulfate sodium – a substance used to induce colitis. Resveratrol also protected colonic mucosa and reduced systemic inflammation. [Source]
• In 2014 The Journal of pharmacology and Experimental Therapeutics published an animal study which found that resveratrol controls inflammation and suppresses intestinal tumor formation in mice. [Source]

Chron’s

• In 2012 Inflammatory Bowel Disease published an animal study which showed that resveratrol administration reduced inflammatory cytokines in rats with chron’s disease – suggesting therapeutic applications in Chron’s and inflammatory bowel disease (IBD). [Source]

Memory and brain function

• In 2014 The Journal of Neuroscience published a study in which 23 overweight, but otherwise healthy adults supplemented 200 mg/day resveratrol for 26 weeks. Compared to 23 adults who received a placebo, the resveratrol group had improved memory performance and significant increases in hippocampal functional connectivity. [Source]
• In 2015 Scientific Reports published an animal study which found that resveratrol improved memory, learning ability, neuron production and mood function in late-middle aged rats, whereas rats in an age-matched control group had impairments in these areas. [Source]
• In 2015 The Public Library of Science published an animal study which found that 2 weeks of resveratrol treatment activated neuron production by increasing cell survival and reducing the rate of cell death in mice. [Source]
• In 2009 the European Journal of Pharmacology published an animal study which showed that 30 days of treatment with resveratrol prevented memory impairment in diabetic rats. [Source]
• In 2012 Diabetes published an animal study in which mice were fed a high-fat diet or a high-fat diet supplemented with resveratrol for 20 weeks. Compared to mice in the high-fat-only group, resveratrol-treated mice showed reductions in fatty liver disease, brain inflammation and insulin resistance and reduced memory deficits. [Source]

Cardiovascular protection

• In 2012 Clinical Hemorheology and Microcirculation published a double-blind study in which 40 patients who had suffered a previous heart attack were given either 10 mg/day resveratrol or a placebo for 3 months. The resveratrol-treated group had a significant decrease in LDL cholesterol and protection against platelet aggregation (blood clot formation) – which was seen in the placebo group. [Source]
• In 2014 the International Journal of Clinical & Experimental Pathology published an animal study which showed that resveratrol administration significantly reversed the harmful effects of an atherogenic diet in rats, while improving antioxidant status. [Source]