Collagen

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Skin elasticity and moisture

In 2014 Skin Pharmacology and Physiology published a double-blind in which 69 women received either 2.5 or 5 grams of collagen hydrolysate or a placebo daily for 8 weeks. At the end of the study period both collagen groups had significantly improved skin elasticity compared to the placebo group. There were no side effects seen in the study. [Source]
In 2016 the Journal of the Science of Food Agriculture published a double-blind study which found that, compared to a placebo, collagen hydrolysate (particularly with higher levels of bioactive collagen peptides) improved facial moisture, elasticity, wrinkles and roughness with no adverse effects. [Source]

In 2004 the International Journal of Tissue Reactions published a double-blind study in which 20 women aged 40-62 years old applied either a 3 percent collagen-like gel or a placebo around the eye twice daily for 4 weeks. Compared to the placebo, the collagen treatment significantly reduced the number, depth and length of wrinkles around the eye. [Source]

In 2013 the Journal of the International Society of Sports Nutrition published a double-blind, placebo-controlled trial involving 55 subjects who reported knee pain during exercise which found that 120 days of supplementation with 40 mg undenatued type II collagen improved knee-joint extension and increased pain-free time during strenuous exertion. [Source]
In 2012 Complementary Therapies in Medicine published a double-blind study in which 200 patients with joint pain received 1200 mg/day collagen hydrolysate or a placebo for 6 months. At the end of the 6 month, period clinical improvement was seen in 51.6 percent of the collagen group compared to 36.5 percent in the placebo group. [Source]

In 2015 the Journal of the Science of Food Agriculture published a double-blind, placebo-controlled trial which fond that collagen peptides improved osteoarthritis symptoms and quality of life scores after 7 weeks. [Source]

In 2016 Nutrition Journal published a double-bind trial in which 191 patients with osteoarthritis of the knee received either undenatured type II collagen (40 mg), glucosamine hydrochloride/chondroitin sulfate (1500 mg G & 1200 mg C) or a placebo for 180 days. At the end of the study period the collagen group had a significant reduction in pain and stiffness and improved physical function compared to both the glucosamine/chondroitin and placebo groups. [Source]

In 2008 Arthritis and Rheumatism published a double-blind study comparing chicken type II collagen with methotrexate for the treatment of rheumatoid arthritis in 211 patients. After 24 weeks both treatments significantly improved symptoms. While methotrexate was the more effective treatment, there were fewer and milder side effects in the collagen group. [Source]
In 2009 Arthritis Research and Therapy published a double-blind study in which 454 rheumatoid arthritis patients received either .1 mg of chicken type II collagen daily or 10 mg of methotrexate once a week for 24 weeks. At the end of the study period 41.5 percent of the collagen group and 57.9 percent of the methotrexate group had greater than 20 percent improvement, with milder and fewer side effects in the collagen group. [Source]

In 2002 the International Journal of Clinical Pharmacology Research published a 42-day pilot study which found that 10 mg/day undenatured type II collagen reduced morning stiffness and pain associated with joint use in 5 females suffering from significant joint pain. [Source]

In 2014 the Journal of the American Academy of Dermatology published a study in which 147 subjects with acne scars received 2 injection sessions with either polymethylmethacrylate (PMMA) collagen or saline injections. The results showed that the collagen group had a 64 percent success rate compared to 33 percent in the saline group. The researchers noted collagen’s excellent safety profile with generally mild, reversible adverse events. [Source]

In 2008 Current Medical Research and Opinion published a double-blind study in which 97 male and female athletes with joint pain and no evidence of joint disease received either 10 grams of liquid collagen hydrolysate or a placebo for 24 weeks. The results showed that those in the collagen group had greater reductions in joint pain at rest and while engaged in physical activity compared to the placebo group. [Source]