- In 2015 the Journal of Clinical and Aesthetic Dermatology published a study in which 10 subjects with different types of acne scars were treated with 6 microneedling sessions at 2-week intervals. Results showed that microneedling effectively stimulated the repair process, increased collagen production and provided noticeable clinical improvements in acne scars.
Subcision, microneedling and TCA peel
- In 2014 the Journal of Cutaneous and Aesthetic Surgery published a study using combination therapy including subcision, microneedling and 15 percent TCA peel. Out of 16 patients with grade 4 scars, 10 improved to grade 2 scars and 6 improved to grade 3 scars. Out of 22 patients with grade 3 scars, 5 were left with no scars, 2 improved to grade 1 scars and 15 improved to grade 2 scars. All 11 patients treated with grade 2 scars were left with no scars.
Microneedling with platelet-rich plasma and vitamin C
- In 2014 the Journal of Cutaneous and Aesthetic Surgery published a study comparing microneedling combined with either PRP (platlet rich plasma) or vitamin C for treating acne scars. Overall results were better with platlet-rich plasma, though vitamin C improved skin firmness and smoothness and reduced post-inflammatory hyper-pigmentation.
Retinoic acid and glycolic acid
- In 2015 the Indian Dermatology Online Journal published a study in which 35 patients underwent treatment of acne scars using retinoic and glycolic acid. After 12 weeks 91 percent of the patients saw a significant improvement in scarring.
- In 2008 the Journal of the European Academy of Dermatology and Venereology published a study involving 22 patients in which subcision treatment mildly improved acne scarring in 60 percent of participants and moderately improved scarring in 40 percent.
Fractional CO2 Laser
- In 2011 the Journal of Cosmetic Dermatology published a study involving 7 adults with acne scars which showed that Fractional CO2 lasers provided clinical improvement in acne scars after 3 weeks and 3 sessions.
- In 2014 the Journal of the American Academy of Dermatology published a study in which 147 subjects with acne scars received 2 injection sessions with either polymethylmethacrylate (PMMA) collagen or saline injections. The results showed that the collagen group had a 64 percent success rate compared to 33 percent in the saline group. The researchers noted collagen’s excellent safety profile with generally mild, reversible adverse events.