• In 2014 Journal of Holistic Nursing published a study in which 7 days of treatment with a topical ginger compress or a ginger patch was able to reduce pain by 48 percent, fatigue by 49 percent, and increase functionality by 31 percent in 20 patients with chronic osteoarthritis. [Source]

Ginger – Osteoarthritis of the Knee

  • In 2001 Arthritis and Rheumatism published a 6-week, double-blind, placebo-controlled trial of 247 patients with osteoarthritis of the knee. Results showed that a highly purified and standardized ginger extract was able to produce a moderate reduction in symptoms with good safety profile. [Source]
  • In 2013 the Indian Journal of Physiology and Pharmacology published a 12-week study involving 60 patients which found that 750 mg/day ginger combined with the NSAID (non-steroidal anti-inflammatory drug) diclofenac was more effective than either ginger or the NSAID alone in treating osteoarthritis of the knee. [Source]
  • In 2011 the Pakistan Journal of Biological Sciences published a double-blind study in which 92 patients with osteoarthritis of the knee used a topical ointment containing ginger or a salicylate ointment twice daily. After 6 weeks the ginger group saw a decrease in pain and morning stiffness comparable with salicylate ointment. [Source]

Yoga – Osteoarthritis of the knee

  • In 2012 the International Journal of Yoga published a study in which 250 patients with osteoarthritis of the knee were assigned to a control group or a yoga group which consisted of 40-minute daily sessions 6 days per week – with both groups receiving transcutaneous electrical stimulation and ultrasound treatment. After 3 months yoga proved to be more effective than physical therapy as an adjunct treatment in reducing knee pain. [Source]
  • In 2014 BMC Complementary and Alternative Medicine published a study in which 36 older subjects with osteoarthritis of the knee were assigned to an 8-week yoga program or a wait list group. Results showed that yoga improved pain, stiffness and function with no adverse effects. [Source]

Yoga – Sedentary adults

  • In 2015 the Journal of Rheumatology published a study in which 75 sedentary adults with rheumatoid arthritis or osteoarthritis of the knee were assigned an 8 week yoga program consisting of two 60-minute classes per week plus 1 in-home session per week or a wait-list. Yoga was associated with clinically significant improvements in physical and mental health, fitness, and psychological function, while safely increasing activity levels. [Source]

Resistance training

  • In 2010 Clinical Geriatric Medicine published a meta-analysis of 8 clinical trials which found that strength training has particularly strong functional benefits for older adults with osteoarthritis. [Source]

Whole food plant-based diet

  • In 2015 Arthritis published a study involving 37 patients with osteoarthritis. Eighteen of the patients were assigned to a control group (no treatment) and 19 patients were placed on a whole-food plant-based diet. After 6 weeks the intervention group (plant-based diet) reported significantly greater improvements in energy, vitality and physical function compared to the control group. [Source]


  • In 2015 the Journal of the Science of Food Agriculture published a double-blind, placebo-controlled trial which fond that collagen peptides improved osteoarthritis symptoms and quality of life scores after 7 weeks. [Source]
  • In 2016 Nutrition Journal published a double-bind trial in which 191 patients with osteoarthritis of the knee received either undenatured type II collagen (40 mg), glucosamine hydrochloride/chondroitin sulfate (1500 mg G & 1200 mg C) or a placebo for 180 days. At the end of the study period the collagen group had a significant reduction in pain and stiffness and improved physical function compared to both the glucosamine/chondroitin and placebo groups. [Source]
  • In 2002 the International Journal of Clinical Pharmacology Research published a 42-day pilot study which found that 10 mg/day undenatured type II collagen  reduced morning stiffness and pain associated with joint use in 5 females suffering from significant joint pain. [Source]

Acupuncture – Osteoarthritis of the knee

  • In 2005 Lancet published a study, including 294 patients, which found that patients who received 12 acupuncture sessions over an 8 week period had reduced pain and improved joint function more than a control group or a minimal acupuncture group. [Source]
  • In 2012 Pain published a single-blind study comparing three treatments for osteoarthritis of the knee in 120 patients. Treatments included acupuncture with an anti-inflammatory drug (etorcoxib), sham acupuncture with etorcoxib or etorcoxib alone. The anti-inflammatory drug with acupuncture was found to be more effective than the drug treatment alone or sham acupuncture with the drug. [Source]
  • in 2004 Acupuncture in Medicine published a 30-patient study which showed that electroacupuncture twice weekly for 5 weeks was more effective in treating osteoarthritis of the knee compared to medication alone. There was no loss of benefit after one month. [Source]


  • In 2004 BMC Musculoskeletal Disorders published a double-blind study comparing 1200 of SAM-e to 200 mg of celecoxib (brand name, Celebrex) for 16 weeks in 56 patients with osteoarthritis of the knee. The results showed that SAM-e is as effective as celecoxib, though it has a slower onset. [Source]
  • In 2002 The Journal of Family Practice published a meta-analysis of 2 studies comparing SAM-e to NSAIDS and a placebo for the treatment of osteoarthritis. The data showed that SAM-e is comparable with NSAIDS for reducing pain and functional limitations associated with osteoarthritis and has the advantage of being much better tolerated. [Source]
  • In 2009 Clinical Therapeutics published an 8-week, double-blind study involving 134 patients which found that 1200 mg/day of SAM-e was as effective as 1000 mg/day of the NSAID (non-steroidal anti-inflammatory drug), nabumetone in treating osteoarthritis of the knee. [Source]


  • In 2014 International Immunopharmocology published an in vitro study which found that astaxanthin reduced the expression of substances related to the onset of osteoarthritis –  leading the authors to conclude that astaxanthin may be useful in treating osteoarthritis. [Source]
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