Guarana – Fatigue associated with chemotherapy

  • In 2011 the Journal of Alternative and Complementary Medicine published a clinical trial in which 65 breast cancer patients receiving chemotherapy were given either a placebo or 50 mg guarana twice daily for 21 days. Compared to the placebo, guarana significantly improved chemotherapy-related fatigue.

Acupuncture – Post chemotherapy fatigue

  • In 2004 the Journal of Clinical Oncology published a study in which 31 patients with severe chemotherapy-related-fatigue saw an average 31 percent improvement in fatigue levels following 6-8 acupuncture treatments. [Source]

Yoga – Fatigue among cancer survivors

  • In 2011 Evidence Based Complementary and Alternative Medicine published a study which demonstrated significant improvements in fatigue as well as depressed mood and physical function in 11 breast cancer survivors who completed a 3-month yoga program. [Source]

Yoga – Fibromyaglia-related fatigue

  • In 2014 Biopsychosocial Medicine published a study in which 30 patients with chronic fatigue syndrome who did not respond to conventional therapy for at least 6 months were assigned to a conventional pharmocotherpay treatment alone or combined with daily yoga sessions for 2 months. Fatigue scores decreased significantly in the yoga group but not in the conventional treatment group. [Source]

Ginseng – Chronic fatigue syndrome

  • In 2013 the Public Library of Science published a 90-patient, double-blind, placebo-controlled trial which found that administration of 2 grams of Panax ginseng daily for 4 weeks provided anti-fatigue effects in patients with idiopathic chronic fatigue. [Source]

Ginseng – Anti-fatigue

  • In 2016 Nutrients published and animal study which found that 30 days of ginseng treatment significantly increased forced swimming time and reduced blood lactic acid in mice, while also counteracting fatigue-induced oxidative stress and reductions in antioxidant enzymes. [Source]
  • In 2016 the Journal of Alternative and Complementary Medicine published a double-blind study involving 52 subjects which found that 4 weeks of supplementation with 2000 mg/day of an enzyme-modified ginseng extract reduced fatigue more than a placebo. [Source]

Ginseng – Anti-fatigue in NAFLD patients

  • In 2016 the Journal of Ginseng Research published a 3-week, placebo-controlled trial involving 80 patients which found that Korean red ginseng may be effective in reducing inflammation and fatigue in overweight patients with non-alcoholic fatty liver disease. [Source]

Ginseng – MS-related fatigue

  • In 2013 the International Journal of Neuroscience published a 60-patient, double-blind, placebo-controlled study in which female patients with multiple sclerosis experienced a reduction in fatigue and a significant positive effect on quality of life after treatment with 250 mg ginseng, twice daily for 3 months. [Source]

Ginseng – Cancer-related fatigue

  • In 2015 Integrative Cancer Therapies published a study in which 24 patients with cancer-related fatigue received high-dose panax ginseng equal to 800 mg daily for 29 days. At the end of the study 87 percent of participants had improved fatigue scores. Significant improvements in quality of life, appetite and sleep were also recorded. [Source]
  • In 2010 Supportive Care in Cancer published a double-blind trial in which 292 patients with cancer-related fatigue were given either a placebo or 750 mg, 1000 mg or 2000 mg of American ginseng twice daily for 8 weeks. Compared to the placebo, over twice as many patients treated with ginseng perceived a reduction in fatigue. [Source]

Royal jelly – Antifatigue

  • In 2001 the Journal of Nutritional Science and Vitaminology published an animal study which found that mice given royal jelly performed better in a swim test compared to a control group. The mice given royal jelly also showed significantly lower levels of lactate acid buildup and higher levels of remaining muscle glycogen after swimming. [Source]

Royal jelly – Cancer-related Fatigue

  • In 2016 Electron Physician published a study which administered royal jelly or royal jelly with honey to 52 cancer patients undergoing treatment. After 2 and 4 weeks the patient group receiving royal jelly had reduced fatigue compared to the honey-only group. [Source]

Modafinil – Decreased fatigue and improved motivation

  • In 2004 Human Psychopharmacology published a double-blind study in which 18 healthy volunteers received either a placebo or an average dose of 300 mg modafinil. Compared to those in the placebo group, subjects who received modafinil experienced improvements in fatigue, motivation, reaction time and vigilance. [Source]

Modafinil – Fatigue caused by Multiple Sclerosis

  • In 2010 The Annals of Pharmacotherapy published a meta-analysis of 6 studies which found that in most of the studies reviewed modafinil had a positive effect of MS-related fatigue. [Source]
  • In 2010 Clinical Neurology and Neurosurgery published a study which found that modafinil was most beneficial to patients when MS-fatigue was accompanied by daytime sleepiness. [Source]
  •  In 2002 the Journal of Neurology published a 3-month study of in which 47 MS patients were treated with 25-300 mg/day modafinil for 3 months. Eighty-seven percent (41 patients) self-reported clear improvement in fatigue. The authors concluded that low dose modafinil significantly improves fatigue and sleepiness and is well tolerated by MS patients. [Source]

Meditation – multiple sclerosis-related fatigue

  • In 2011 the International Journal of MS Care published a study in which 22 patients with either multiple sclerosis or peripheral neuropathy participated in weekly meditation classes over a 2-month period. Compared to a control group, the meditation group saw significant improvements in pain, physical and mental health scores and fatigue. [Source]

Modafinil – Severe cancer related fatigue

  • In 2010 Cancer published a double-blind, placebo-controlled trial of 867 cancer patients undergoing chemotherapy. The results showed that 200 mg/day modafinil was effective in reducing fatigue in patients with severe fatigue but not those with mild or moderate fatigue. [Source]

Vitamin C

  • In 2012 Nutrition Journal published a double-blind clinical trial in which 141 healthy office workers received either 10 grams of IVC (intravenous vitamin C) or a placebo (in IV form). Fatigue scores measured both 2 hours and one day after administration were significantly lower in participants of the vitamin C group who had low baseline levels of vitamin C. [Source]

CoQ10 – Prevents Fatigue Caused by Multiple Sclerosis

  • In 2016 Nutritional Neuroscience published a double-blind clinical trial which found that 500 mg per day of CoQ10 was able to improve both fatigue and depression symptoms in patients with multiple sclerosis. [Source]

CoQ10 – Fibromyalgia-related fatigue

  • In 2013 Redox Report published a study which linked juvenile fibromyalgia to deficient levels of coenzyme Q10. Results showed that 100 mg/day CoQ10 for 12 weeks in fibromyalgia patients lead to reductions in cholesterol and reduced symptoms of chronic fatigue. [Source]
  • In 2015 Antioxidants & Redox Signaling published a double-blind study in which 73 patients with chronic fatigue syndrome – a disorder common in fibromyaglia patients – were treated with either 200 mg/day CoQ10 and 20 mg/day NADH or a placebo for 8 weeks. Results showed that CoQ10/NADH significantly reduced fatigue and improved biochemical parameters of CFS with no adverse effects. [Source]


  • In 2009 the Journal of Sports Medicine and Physical Fitness published a double-blind, crossover study in which a drink containing BCAAs reduced muscle soreness, fatigue and inflammation more than a placebo when consumed by 12 long distance runners on workout days. [Source]
  • In 2011 The Journal of Sports Medicine and Physical Fitness published a double-blind study in which 7 volunteers consumed either a BCAA supplement or a placebo for 3 days, with an exercise-induced glycogen depletion protocol on day 2 and an exhaustive exercise test on the third day. The BCAA group had a greater resistance to fatigue on day 3 compared to a placebo group. [Source]


  • In 2008 Nutrition Research published a double-blind, placebo-controlled, crossover study including 17 volunteers which found that ornithine promoted fat metabolism and delayed fatigue during physical exercise. [Source]

Skipping breakfast – increased fatigue and poor attention

  • In 2014 Ghana Medical Journal published a study based on questionnaires of 317 medical students which revealed that skipping breakfast was related to fatigue and poor attention during clinical sessions. [Source]

Massage – Cancer patients

  • In 2004 the Journal of Pain and Symptom Management published a 3-year study which found that massage therapy reduced pain, fatigue, stress and other symptoms by approximately 50 percent in 1,290 cancer patients who were treated over a 3-year period. [Source]


  • In 2016 Medicine and Science in Sports and Exercise published a study in which 32 adult men with self-reported ADHD who spent 20 minutes cycling experienced motivation for cognitive tasks, increased feelings of energy and reduced feelings of confusion, fatigue and depression. [Source]

Physical activity – IBS-related fatigue

  • In 2015 the World Journal of Gastroenterology published a study in which 39 patients saw significant improvements in IBS symptoms, as well as improvements in fatigue, anxiety and depression after completing a 12-week period of increased physical activity. [Source]


  • In 2016 the Brazilian Journal of Physical Therapy published a study which found that 30 participants had significantly lower anxiety, depression, anger, fatigue and body weight after walking 10,000 steps per day for 12 weeks, compared to before the intervention. [Source]

Water intake

  • In 2014 the Public Library of Science published a study in which 22 individuals with high water intake (2.5 L/day) reduced their intake to 1 L/day and 30 participants with low water intake (1 L/day) increased their consumption to 2.5 L/day. The result was a decrease in happiness, calmness, positive emotions and vigor in the group with reduced water, while those who increased water consumption saw significant decreases in fatigue, confusion and thirst as well as lower sleepiness compared to baseline. [Source]

Ginger – Osteoarthritis-related fatigue

  • In 2014 Journal of Holistic Nursing published a study in which 7 days of treatment with a topical ginger compress or a ginger patch was able to reduce pain by 48 percent, fatigue by 49 percent, and increase functionality by 31 percent in 20 patients with chronic osteoarthritis. [Source]

Omega 3s and bilberry extract, and lutein – Eye strain-related fatigue

  • In 2011 Biomedical Research published a double-blind, placebo-controlled study in which 4 weeks of treatment with a supplement containing fish oil, bilberry extract and lutein improved asthenopia (eye strain) and associated mental fatigue in 11 individuals when compared to a placebo group. [Source]

Creatine – Increased fatigue threshold in elderly individuals

  • In 2007 The Journal of Nutrition, Health & Aging published a double-blind study in which 15 men and women, with an average age of 75 years, were assigned to either creatine or a placebo for 14 days. Results showed significant increases in grip strength and fatigue threshold. [Source]
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